William Preston
William Preston may refer to:
- William Preston (actor)
- William Preston (Freemason), Scottish author of Illustrations of Masonry
- William Preston (Kentucky soldier), U.S. politician, ambassador, and Confederate officer
- William Preston (poet), Irish poet
- William Preston (Virginia soldier), Irish-born frontier Virginia leader, signer of the Fincastle Resolutions
- William Preston (Royal Navy officer), captain in the British Royal Navy who, along with James Stirling, was responsible for the foundations of Perth and Fremantle in Western Australia
- William Preston (British politician), Conservative M.P. for Walsall, 1924–1929
- William Alfred Preston, MPP in Ontario, Canada
- William B. Preston (Mormon), Presiding Bishop of the Church of Jesus Christ of Latter-day Saints, 1884–1907
- William B. Preston, U.S. politician from Virginia
- William C. Preston, U.S. politician from Pennsylvania who was a U.S. senator for South Carolina
- William G. Preston, American architect
- William Preston (bishop), Anglican bishop in Ireland
- Billy Preston, American musician
- Billy Preston (basketball), American basketball player
- Bill Preston, American football tackle
Fictional
- Sergeant William Preston of the Northwest Mounted Police, lead character in the radio and TV series ''Challenge of the Yukon''