Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells
Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells is a scholarly work by Kathy O Lui, published in 2014 in ''Cell Research''. The main subjects of the publication include embryonic stem cell, immunology, progenitor cell, cell potency, cancer research, endothelium, endothelial stem cell, biology, Notch signaling pathway, induced pluripotent stem cell, pluripotency, cell biology, angiogenesis, stem cell, and development of the heart. This sequential approach generated > 50% conversion of hPSCs to endothelial cells (ECs), specifically VEC(+)CD31(+)CD34(+)CD14(-)KDR(high) endothelial progenitors (EPs) that exhibited higher angiogenic and clonogenic proliferation potential among endothelial lineage cells.